LD-based PICS Probabilities for Index SNPs
Original PICS functionality extended with batch processing; result file download; 1000 Genomes Reference data for ALL, EUR, EAS, SAS, AFR, and AMR populations; and GRCh38 positions.
PICS Probabilities from summary statistics
Determine PICS probabilities from p-values within windows around significant SNPs.
Data Portal
Download PICS 2.0 Autoimmune Disease and GWAS catalog SNPs. GWAS catalog SNPs are updated and fine-mapped weekly.
References
Kimberly E Taylor, K Mark Ansel, Alexander Marson, Lindsey A Criswell, Kyle Kai-How Farh, PICS2: Next-generation fine mapping via probabilistic identification of causal SNPs, Bioinformatics, 2021;, btab122, https://doi.org/10.1093/bioinformatics/btab122
Farh,K.K. et al. (2015) Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature, 518, 337–343. (PICS 1)